Polymersomes: Small 10/2009
نویسندگان
چکیده
منابع مشابه
Polymersomes.
Polymersomes are self-assembled polymer shells composed of block copolymer amphiphiles. These synthetic amphiphiles have amphiphilicity similar to lipids, but they have much larger molecular weights, so for this reason--along with others reviewed here--comparisons of polymersomes with viral capsids composed of large polypeptide chains are highly appropriate. We summarize the wide range of polym...
متن کاملPolymersomes in polymersomes: multiple loading and permeability control.
Polymer vesicles polymersomes are vesicles obtained from the self-assembly of amphiphilic block copolymers in aqueous solution as a result of free-energy minimization. Their potential use as drug delivery systems, sensors, and/or nanoreactors has recently attracted a great deal of interest. Polymersomes exhibit larger mechanical stability and lower permeability than liposomes, their structural ...
متن کاملParamagnetic Porous Polymersomes
The ability of chelated Gd to serve as an effective magnetic resonance (MR) contrast agent largely depends on fast exchange rates between the Gd-bound water molecules and the surrounding bulk water. Because water diffuses slowly across lipid bilayers, liposomes with encapsulated chelated Gd have not been widely adopted as MR contrast agents. To overcome this limitation, we have synthesized chem...
متن کاملElectromechanical limits of polymersomes.
Self-assembled membranes of amphiphilic diblock copolymers enable comparisons of cohesiveness with lipid membranes over the range of hydrophobic thicknesses d = 3-15 nm. At zero mechanical tension the breakdown potential V(c) for polymersomes with d = 15 nm is 9 V, compared to 1 V for liposomes with d = 3 nm. Nonetheless, electromechanical stresses at breakdown universally exhibit a V(c)(2) dep...
متن کاملCascade reactions in multicompartmentalized polymersomes.
Enzyme-filled polystyrene-b-poly(3-(isocyano-L-alanyl-aminoethyl)thiophene) (PS-b-PIAT) nanoreactors are encapsulated together with free enzymes and substrates in a larger polybutadiene-b-poly(ethylene oxide) (PB-b-PEO) polymersome, forming a multicompartmentalized structure, which shows structural resemblance to the cell and its organelles. An original cofactor-dependent three-enzyme cascade r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Small
سال: 2009
ISSN: 1613-6810,1613-6829
DOI: 10.1002/smll.200990048